It seems that there is a historical confrontation between domestic and outside environment in defining the main role of Iranian Foreign Policy. While the domestic variables encourage idealism, asertiveness and becoming a regional dominant power, international system has been the main obstacle to realize the ambitious goals. Due to growing the importance of outside variables in the globalizing world and particularly in the aftermath of 9/11 events, re-emerging and reinforcing of mentioned confrontation is possible again. In this regard, the present article argues that having an effective strategy in Iran's foreign policy is dependant on considering four variables in four levels. Although it is too difficult to find a solution for this confrontation in near future, having an effective strategy may reduce its negative consequences.