Based on the recommendations of the Secretary General's Panel of Eminent Persons, the United Nations has recently introduced changes to the Human Rights Commission. In the long term, it has considered upgrading the commission to become a Human Rights Council. This paper offers a critique of this structural reform, arguing that limited reform of the institution cannot move forward without making the human rights system perform effectively. The argument proceeds that to strengthen this body requires a collaborative process to rebuild the capacity and deploy and manage human rights, collectively. In this context an interdisciplinary approach is used to discuss the report of the Secretary General's High-Level Panel: A More Secure World, Kofi Annan's report: In a Larger Freedom, and The 2005 World Summit Outcome together. The author provides an analysis of the issues relating to this change such as membership and structure and some challenges could be a threat for human rights protection and promotion in our world. The author brings a unique Iranian approach to these pressing issues in the areas of human rights and UN reform and offers a critique from the perspective of the global South.